1-(4-Bromophenyl)-2,2-difluoroethan-1-ol → 2-(4-(2,2-Difluoro-1-hydroxyethyl)phenyl)-8-(isobutylsulfonyl)-2,8-diazaspiro[4.5]decan-1-one
Reaction equation
[Br:49][c:50]1[cH:51][cH:52][c:53]([CH:54]([OH:55])[CH:56]([F:57])[F:58])[cH:59][cH:60]1.[CH2:19]([CH:20]([CH3:21])[CH3:22])[S:23](=[O:24])(=[O:25])[N:26]1[CH2:27][CH2:28][C:29]2([CH2:30][CH2:31][N:32]([c:35]3[cH:36][cH:37][c:38]([CH:41]([C:42]([F:43])([F:44])[F:45])[OH:46])[cH:39][cH:40]3)[C:33]2=[O:34])[CH2:47][CH2:48]1.[CH2:1]([S:2]([N:3]1[CH2:4][CH2:5][C:6]2([C:7](=[O:8])[NH:9][CH2:10][CH2:11]2)[CH2:12][CH2:13]1)(=[O:14])=[O:15])[CH:16]([CH3:17])[CH3:18]>>[CH2:19]([CH:20]([CH3:21])[CH3:22])[S:23](=[O:24])(=[O:25])[N:26]1[CH2:27][CH2:28][C:29]2([CH2:30][CH2:31][N:32]([c:35]3[cH:36][cH:37][c:38]([CH:41]([CH:42]([F:43])[F:44])[OH:46])[cH:39][cH:40]3)[C:33]2=[O:34])[CH2:47][CH2:48]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-c9c603f9d0424b61ae195d5a90b410a3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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