Dichloromethane → 2-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

HRID 680726Notes

Reaction equation

HRID 680726 reaction equation
[Cl:49][CH2:50][Cl:51].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48].[N:1](=[N+:2]=[N-:3])[CH2:4][CH2:5][CH2:6][C:7]1([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[S:8][C:9]([c:28]2[c:29]([F:35])[cH:30][cH:31][c:32]([F:34])[cH:33]2)=[N:10][N:11]1[c:12]1[s:13][c:14]2[c:19]([n:20]1)[CH2:18][CH2:17][N:16]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:15]2>>[N:1](=[N+:2]=[N-:3])[CH2:4][CH2:5][CH2:6][C:7]1([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[S:8][C:9]([c:28]2[c:29]([F:35])[cH:30][cH:31][c:32]([F:34])[cH:33]2)=[N:10][N:11]1[c:12]1[s:13][c:14]2[c:19]([n:20]1)[CH2:18][CH2:17][NH:16][CH2:15]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86608771tert-butyl 2-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

Product 1

HCID 866087722-(2-(3-azidopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine

Sources & evidence

ORD record
ord-0326840bd561424e979885b03453089e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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