Dichloromethane → 1-(2-amino-3-(1H-indol-3-yl)propionyl)-4-benzylpiperidine-4-carboxylic acid N',N'-dimethylhydrazide

HRID 681118Notes

Reaction equation

HRID 681118 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][CH:8]([C:9](=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([C:17](=[O:18])[NH:19][N:20]([CH3:21])[CH3:22])([CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:15][CH2:16]1)[CH2:30][c:31]1[cH:32][nH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]12)([CH3:5])([CH3:6])[CH3:40].[CH2:48]([Cl:49])[Cl:50].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[NH2:7][CH:8]([C:9](=[O:10])[N:11]1[CH2:12][CH2:13][C:14]([C:17](=[O:18])[NH:19][N:20]([CH3:21])[CH3:22])([CH2:23][c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:15][CH2:16]1)[CH2:30][c:31]1[cH:32][nH:33][c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]12

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 20694720(2-(4-benzyl-4-(N',N'-dimethylhydrazinocarbonyl)piperidine-1-yl)-1-(1H-indole-3-ylmethyl)-2-oxoethyl)carbamic acid tert-butyl ester

Product 1

HCID 206947011-(2-amino-3-(1H-indol-3-yl)propionyl)-4-benzylpiperidine-4-carboxylic acid N',N'-dimethylhydrazide

Sources & evidence

ORD record
ord-2944d1b97a274fd787a0eeca5256ab18
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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