Water → 8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

HRID 681302Notes

Reaction equation

HRID 681302 reaction equation
[Br:1][CH2:2][c:3]1[cH:4][c:5]2[n:6][c:7]([Cl:18])[n:8][c:9]([N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:10]2[s:11]1.[C:29](=[O:30])([O-:31])[O-:32].[Cs+:33].[Cs+:34].[O:19]1[CH2:20][CH2:21][O:22][C:23]12[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]2.[O:35]=[CH:36][N:37]([CH3:38])[CH3:39].[OH2:40]>>[CH2:2]([c:3]1[cH:4][c:5]2[n:6][c:7]([Cl:18])[n:8][c:9]([N:12]3[CH2:13][CH2:14][O:15][CH2:16][CH2:17]3)[c:10]2[s:11]1)[N:26]1[CH2:25][CH2:24][C:23]2([O:19][CH2:20][CH2:21][O:22]2)[CH2:28][CH2:27]1

Participants

7

Reactant 6

HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 104967Cesium cation2×HCID 461807264-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine

Product 1

HCID 581170818-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

Sources & evidence

ORD record
ord-68bd1e3ff99547cdb4af10165d6edc45
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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