HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 6814Generated: October 27, 2026
Sodium Carbonate → HCID 178419012, compound
https://huagongshe.com/reaction/6814
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | N-[1-(6-cyanoquinolin-2-yl)pyrrolidin-3-yl]-2,2-dimethylpropanamide | HCID 22018989 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178419012 | HCID 178419012 | — |
Reaction Steps
A mixture of the product of Step D (60 mg; 0.1863 mmol), hydroxyl amine hydrochloride (3 eq.), sodium carbonate (4 eq.) in 1.5 mL water and 2.5 mL ethanol was heated to 90° C. for 6 h. The mixture was diluted with dichloromethane, washed twice with brine, dried over sodium sulfate, filtered through a fritted funnel and the volatiles were removed under vacuum. This provided the product, MS: m/z 356, which was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07084156B2 |
|---|
| Source dataset | uspto-grants-2006_08 |
|---|
| ORD ID | ord-410a6f1443c34331ba6735f7cc64c911 |
|---|
| Source note | uspto-grants-2006_08 |
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