反应详情

温度

90 °C

A mixture of the product of Step D (60 mg; 0.1863 mmol), hydroxyl amine hydrochloride (3 eq.), sodium carbonate (4 eq.) in 1.5 mL water and 2.5 mL ethanol was heated to 90° C. for 6 h. The mixture was diluted with dichloromethane, washed twice with brine, dried over sodium sulfate, filtered through a fritted funnel and the volatiles were removed under vacuum. This provided the product, MS: m/z 356, which was used in the next step without further purification.

1. washwashed twice with brine
2. dry with materialdried over sodium sulfate
3. filtrationfiltered through a fritted funnel
4. customthe volatiles were removed under vacuum
5. customThis provided the product, MS
6. customm/z 356, which was used in the next step without further purification