Hydrogen chloride-ethyl acetate → HCID 67416989, compound

HRID 68171Notes

Reaction equation

HRID 68171 reaction equation
C(OC(=O)C)C.[ClH:7].C(OC([CH2:15][NH:16][CH2:17][C:18]([O:20][CH2:21][N:22]1[C:31]2[C:26](=[C:27]([F:36])[CH:28]=[CH:29][C:30]=2[O:32][CH2:33][CH2:34][CH3:35])[C:25](=[O:37])[C:24]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=2)=[CH:23]1)=[O:19])=O)(C)(C)C>C(OCC)(=O)C>[ClH:7].[CH3:15][NH:16][CH2:17][C:18]([O:20][CH2:21][N:22]1[C:31]2[C:26](=[C:27]([F:36])[CH:28]=[CH:29][C:30]=2[O:32][CH2:33][CH2:34][CH3:35])[C:25](=[O:37])[C:24]([C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[CH:40][CH:39]=2)=[CH:23]1)=[O:19]

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86675424HCID 86675424, compound

Product 1

HCID 67416989HCID 67416989, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A 4N hydrogen chloride ethylacetate solution (1 ml) was added to an ethyl acetate solution (2 ml) of 5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-ylmethyl (tert-butoxycarbonylmethylamino)acetate (100 mg, 0.19 mmol) and stirred at room temperature for 3 hours. The deposited insoluble matter was collected by filtration, washed with acetone, and then dried, giving a white powder of 5-fluoro-3-(4-methoxyphenyl)-4-oxo-8-propoxy-4H-quinolin-1-ylmethyl methylaminoacetate hydrochloride (78.3 mg, yield: 88%).

Workup

  1. filtrationThe deposited insoluble matter was collected by filtration
  2. washwashed with acetone
  3. customdried

Sources & evidence

ORD record
ord-1a82367606764c0d8c31ebcf550338c2
Source dataset
uspto-grants-2014_09
Patent number
USRE045108E1

Reaction notes

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