反应详情

The product of 1f (4.81 mmol) was dissolved in a saturated solution of HCl in ethanol (250 mL), the mixture stirred at room temperature over night and then evaporated to dryness at 30° C. The remaining raw material was dissolved in 200 mL dry ethanol, then ammonium carbonate (48.1 mmol) was added and the mixture stirred at room temperature over night. After evaporation of the solvent the remaining raw material was triturated with ca. 5 mL ethanol, the undissolved material separated by filtration and the solvent evaporated at 30° C. The product was then dissolved in 30 mL water, the solution stirred with ca. 2 g charcoal, filtered and evaporated to dryness.

1. customevaporated to dryness at 30° C
2. dissolutionThe remaining raw material was dissolved in 200 mL dry ethanol
3. stirringthe mixture stirred at room temperature over night
4. customAfter evaporation of the solvent the remaining raw material
5. customwas triturated with ca. 5 mL ethanol
6. customthe undissolved material separated by filtration
7. customthe solvent evaporated at 30° C
8. dissolutionThe product was then dissolved in 30 mL water
9. stirringthe solution stirred with ca. 2 g charcoal
10. filtrationfiltered
11. customevaporated to dryness