反应详情

The product of 2b (1.34 mmol) was added to a saturated HCl solution in dry ethanol (30 mL). The solution was stirred at room temperature for 5 hours, then evaporated to dryness at 30° C. Ethanol (30 mL) and ammonium carbonate (13.0 mmol) were added and the mixture stirred at room temperature over night. The solvent was then evaporated, the residual material was triturated 5 times with ca. 4 mL of a mixture of dichloromethane/methanol (30:1), filtered and evaporated in order to separate the product from inorganic salts.

1. customevaporated to dryness at 30° C
2. stirringthe mixture stirred at room temperature over night
3. customThe solvent was then evaporated
4. customthe residual material was triturated 5 times with ca. 4 mL of a mixture of dichloromethane/methanol (30:1)
5. filtrationfiltered
6. customevaporated in order
7. customto separate the product from inorganic salts