反应详情

To a solution of the product of step 1 (49 g, 0.2076 moles) in methanol (343 ml), hydroxylamine hydrochloride (28.6 g, 0.4152 moles) and a solution of sodium acetate (34 g, 0.4152 moles) in water (147 ml) were added and the reaction mixture was refluxed for 1 hour. The solvents were evaporated under reduced pressure. The residue was dissolved in water and extracted with ethyl acetate. The combined ethyl acetate extract was washed with water & brine, dried over sodium sulphate and evapourated under reduced pressure to yield 40 gm (76%) of product as solid.

1. temperaturethe reaction mixture was refluxed for 1 hour
2. customThe solvents were evaporated under reduced pressure
3. dissolutionThe residue was dissolved in water
4. extractionextracted with ethyl acetate
5. extractionThe combined ethyl acetate extract
6. washwas washed with water & brine
7. dry with materialdried over sodium sulphate