反应详情

To a solution of N-(4-(1-(hydroxyimino)propyl)phenyl)acetamide (6 gm, 0.0291 moles) in DMF (60 mL), cesium carbonate (18.9 gm, 0.0582 moles) and 4-(trifluoromethyl)benzyl bromide (6.96 gm, 0.0291 moles) were added and the reaction mixture was srirred at 25° C. for 3 hours. The reaction mixture was poured into ice cold water and extracted with ethyl acetate. The combined ethyl acetate extract was washed with water & brine, dried over sodium sulphate and evaporated under reduced pressure to yield 10 gm (94%) of product as solid.

1. additionThe reaction mixture was poured into ice cold water
2. extractionextracted with ethyl acetate
3. extractionThe combined ethyl acetate extract
4. washwas washed with water & brine
5. dry with materialdried over sodium sulphate
6. customevaporated under reduced pressure