Chlorotrimethylsilane → Ethyl 3-(cyclopentylamino)-2,2-difluoropropanoate
Reaction equation
[Br:6][C:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])([F:13])[F:14].[Cl:1][Si:2]([CH3:3])([CH3:4])[CH3:5].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[Zn:36].[n:15]1([CH2:24][NH:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30]2)[c:16]2[cH:17][cH:18][cH:19][cH:20][c:21]2[n:22][n:23]1>>[C:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])([F:13])([F:14])[CH2:24][NH:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1Participants
6
Sources & evidence
- ORD record
- ord-9d03b208f5df419d8a8aab3694cf0e65
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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