Potassium Carbonate → 4-Tert-butyl-1-ethynyl-2-nitrobenzene

HRID 68451Notes

Reaction equation

HRID 68451 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][Si](C)(C)C)=[C:7]([N+:17]([O-:19])=[O:18])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]#[CH:12])=[C:7]([N+:17]([O-:19])=[O:18])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58016188(4-tert-Butyl-2-nitro-phenylethynyl)-trimethyl-silane

Product 1

HCID 580162084-Tert-butyl-1-ethynyl-2-nitrobenzeneYield 81.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(4-tert-Butyl-2-nitro-phenylethynyl)-trimethyl-silane (3.167 g, 11.51 mmol) and potassium carbonate (3.18 g, 23.0 mmol) were stirred in 75 mL methanol for 20 minutes. The resulting mixture was partitioned between ethylacetate and water. The ethylacetate layer was washed with brine, dried over anhydrous MgSO4, concentrated in vacuo, and purified by flash chromatography with gradient elution with 0 to 5% ethylacetate/hexanes to yield 4-tert-Butyl-1-ethynyl-2-nitro-benzene (1.910 g, 9.398 mmol).

Workup

  1. customThe resulting mixture was partitioned between ethylacetate and water
  2. washThe ethylacetate layer was washed with brine
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo
  5. custompurified by flash chromatography with gradient elution with 0 to 5% ethylacetate/hexanes

Sources & evidence

ORD record
ord-8b5bd90862674a7f81336624c6c2e720
Source dataset
uspto-grants-2014_09
Patent number
US08822457B2

Reaction notes

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