反应详情

30.95 g (347 mmol) of 2-amino-2-methyl-1-propanol was weighed into a 500 mL Erlenmeyer flask fitted with a stir bar and septum. Added 200 mL CH2Cl2. Established and maintained nitrogen atmosphere. Stirred the solution in an ice/water bath. Added 34 mL (174 mmol) of 4-tert-butylbenzoyl chloride dropwise over 30 min. A white precipitate formed. Stirred at room temperature overnight. Removed the solids by filtration and washed with CH2Cl2. Removed the solvent from the filtrate on rotavap and dried at 60°/4 torr to obtain 45.79 g of the title compound as a light yellow resin. MS (EST) 248 (M−H)−.

1. customfitted with a stir bar
2. temperatureEstablished and maintained nitrogen atmosphere
3. customA white precipitate formed
4. stirringStirred at room temperature overnight
5. customRemoved the solids
6. filtrationby filtration
7. washwashed with CH2Cl2
8. customRemoved the solvent from the filtrate on rotavap
9. customdried at 60°/4 torr