Methyl 2-chloropyrimidine-5-carboxylate → 2-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzyloxy}-pyrimidine-5-carboxylic acid methyl ester

HRID 684729Notes

Reaction equation

HRID 684729 reaction equation
[CH3:25][O:26][C:27](=[O:28])[c:29]1[cH:30][n:31][c:32]([Cl:35])[n:33][cH:34]1.[Cl:1][c:2]1[c:3]([CH:10]([C:11]([C:12]([F:13])([F:14])[F:15])([OH:16])[c:17]2[cH:18][c:19]([Cl:23])[n:20][cH:21][cH:22]2)[CH3:24])[cH:4][cH:5][c:6]([CH2:8][OH:9])[cH:7]1>>[Cl:1][c:2]1[c:3]([CH:10]([C:11]([C:12]([F:13])([F:14])[F:15])([OH:16])[c:17]2[cH:18][c:19]([Cl:23])[n:20][cH:21][cH:22]2)[CH3:24])[cH:4][cH:5][c:6]([CH2:8][O:9][c:32]2[n:31][cH:30][c:29]([C:27]([O:26][CH3:25])=[O:28])[cH:34][n:33]2)[cH:7]1

Participants

3

Reactant 2

HCID 12627752Methyl 2-chloropyrimidine-5-carboxylateHCID 252544493-(2-Chloro-4-hydroxymethyl-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol

Product 1

HCID 723105762-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-benzyloxy}-pyrimidine-5-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-aaa2829111e842d69d633f0f78a504ca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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