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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 684915Generated: November 1, 2026

1,2-Dichloroethane → 4-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline

https://huagongshe.com/reaction/684915

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantPhosphorus oxychlorideHCID 24813—
ReactantDiisopropylethylamineHCID 81531—
Reactant7-Fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-oneHCID 135742095—
Product4-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazolineHCID 22140799—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (3/10)
ORD IDord-6078a55f999d455a98bf253b9ab2d68d
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (3/10)