1,2-Dichloroethane → 4-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline

HRID 684915Notes

Reaction equation

HRID 684915 reaction equation
[CH:25]([N:26]([CH:27]([CH3:28])[CH3:29])[CH2:30][CH3:31])([CH3:32])[CH3:33].[Cl:34][CH2:35][CH2:36][Cl:37].[F:1][c:2]1[cH:3][c:4]([O:13][CH:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:5]2[c:6](=[O:12])[nH:7][cH:8][n:9][c:10]2[cH:11]1.[P:20]([Cl:21])([Cl:22])([Cl:23])=[O:24]>>[F:1][c:2]1[cH:3][c:4]([O:13][CH:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[c:5]2[c:6]([Cl:22])[n:7][cH:8][n:9][c:10]2[cH:11]1

Participants

5

Reactant 4

HCID 111,2-DichloroethaneHCID 24813Phosphorus oxychlorideHCID 81531DiisopropylethylamineHCID 1357420957-Fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4(3H)-one

Product 1

HCID 221407994-Chloro-7-fluoro-5-tetrahydropyran-4-yloxyquinazoline

Sources & evidence

ORD record
ord-6078a55f999d455a98bf253b9ab2d68d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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