反应详情

First, 280 g of 2-nitro-9,10-dihydrophenanthrene, 2.0 g of palladium carbon, and 2.5 L of ethanol were loaded, and then 140 mL of hydrazine monohydrate were added to the mixture. The reaction solution was stirred for 4 hours under heating reflux. After having been cooled to room temperature, the reaction solution was poured into 5 L of water. Then, the mixture was extracted with 3 L of toluene. After the water layer had been removed, the organic layer was dried with magnesium sulfate. After magnesium sulfate had been separated by filtration, the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 220 g of a pale yellow solid were obtained (in 89% yield).

1. temperatureunder heating
2. temperaturereflux
3. extractionThen, the mixture was extracted with 3 L of toluene
4. customAfter the water layer had been removed
5. dry with materialthe organic layer was dried with magnesium sulfate
6. customAfter magnesium sulfate had been separated by filtration
7. customthe solvent was removed by distillation under reduced pressure
8. customThe residue was purified by silica gel column chromatography