Hydrochloric Acid → 2-Iodo-9,10-dihydrophenanthrene

Under an argon atmosphere, 220 g of 2-amino-9,10-dihydrophenanthrene, 3 L of 3N HCl, and 2 L of acetic acid were added, and then the mixture was stirred for 3 hours under heat. After having been cooled to room temperature, the mixture was cooled with ice, and then an aqueous solution of 91 g of sodium nitrite was dropped to the mixture. After the resultant mixture had been stirred for 1 hour under ice cooling, an aqueous solution of 660 g of potassium iodide was added to the mixture. Subsequently, 2 L of dichloromethane were added to the mixture, and then the whole was stirred at room temperature for 3 hours. After that, the mixture was extracted with dichloromethane. The organic layer was repeatedly washed with an aqueous solution of potassium carbonate, and was then dried with magnesium sulfate. After that, the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 210 g of a pale yellow solid were obtained (in 62% yield).

1. temperatureunder heat
2. temperaturethe mixture was cooled with ice
3. stirringthe whole was stirred at room temperature for 3 hours
4. extractionAfter that, the mixture was extracted with dichloromethane
5. washThe organic layer was repeatedly washed with an aqueous solution of potassium carbonate
6. dry with materialwas then dried with magnesium sulfate
7. customAfter that, the solvent was removed by distillation under reduced pressure
8. customThe residue was purified by silica gel column chromatography

ORD record

ord-8360170e64be4ecaa652d3fdf39f2c94

Source dataset

uspto-grants-2014_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08822041B2