1-Chloro-4-isocyanato-2-(trifluoromethyl) benzene → 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(3-oxo-3,4-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

HRID 685184Notes

Reaction equation

HRID 685184 reaction equation
[F:21][C:22]([c:23]1[cH:24][c:25]([N:30]=[C:31]=[O:32])[cH:26][cH:27][c:28]1[Cl:29])([F:33])[F:34].[NH2:1][c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1>>[NH:1]([c:2]1[c:3]([F:20])[cH:4][c:5]([O:6][c:7]2[cH:8][cH:9][n:10][c:11]3[nH:12][c:13](=[O:17])[cH:14][n:15][c:16]23)[cH:18][cH:19]1)[C:31]([NH:30][c:25]1[cH:24][c:23]([C:22]([F:21])([F:33])[F:34])[c:28]([Cl:29])[cH:27][cH:26]1)=[O:32]

Participants

3

Reactant 2

HCID 27332651-Chloro-4-isocyanato-2-(trifluoromethyl) benzeneHCID 469009328-(4-amino-3-fluorophenoxy)pyrido[2,3-b]pyrazin-3(4H)-one

Product 1

HCID 441317111-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-(3-oxo-3,4-dihydro pyrido[2,3-b]pyrazin-8-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-b7a5d22dc3984daeae24090983aa3580
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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