反应详情

Intermediate V (62 g, 0.232 mol) and tetrahydropyrrole (82.46 g, 1.16 mol) were added to acetonitrile (620 mL). The mixture was heated under reflux for 8 h. After completion of the reaction, a portion of solvent was evaporated off. The reaction vessel was placed in a cold trap. The reaction was filtered by suction. The filtered cake was washed with ethyl acetate to produce a yellow solid (66.74 g) in a yield of 95.3%.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 8 h
3. customAfter completion of the reaction
4. customa portion of solvent was evaporated off
5. customThe reaction vessel was placed in a cold trap
6. filtrationThe reaction was filtered by suction
7. washThe filtered cake was washed with ethyl acetate