反应详情

温度

0 °C

Intermediate b (21 g, 0.08 mol) and anhydrous sodium acetate (29 g, 0.35 mol) were added to glacial acetic acid (20v/w, 420 mL). The mixture was warmed up to react under reflux for 2 h. After completion of the reaction, the reaction solution was cooled to 0° C. and poured into water (1200 mL). The mixture was stirred for 30 min and filtered by suction. The filtered cake was washed with water and petroleum ether, and dried to produce an orange red solid (12 g) in a yield of 67.8%.

1. temperatureThe mixture was warmed up
2. customto react
3. temperatureunder reflux for 2 h
4. customAfter completion of the reaction
5. filtrationfiltered by suction
6. washThe filtered cake was washed with water and petroleum ether
7. customdried