Acetic Acid → HCID 86696921, compound

HRID 68547Notes

Reaction equation

HRID 68547 reaction equation
[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH2:14][C:15]3C=CC=[CH:17][CH:16]=3)[C:10](=[O:21])C(C#N)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:25]([OH:28])(=[O:27])[CH3:26]>>[C:1]1([N:7]2[C:12](=[O:13])[N:11]([CH2:14][CH2:15][CH2:16][CH3:17])[C:10](=[O:21])[C:26]([C:25]([OH:28])=[O:27])=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 563927HCID 563927, compound

Product 1

HCID 86696921HCID 86696921, compoundYield 55%

Conditions

Temperature
120 °C

Procedure

Intermediate j (9.2 g, 0.035 mol) was added to a mixed solvent of glacial acetic acid (100 mL) and HCl (72 mL, 0.86 mol). The mixture was warmed up to 120° C. and reacted under reflux for 4 h. The solvent was evaporated off. To the obtained fraction was added water (200 mL). The mixture was filtered by suction and dried to produce Intermediate g (6.5 g) in a yield of 55%.

Workup

  1. customreacted
  2. temperatureunder reflux for 4 h
  3. customThe solvent was evaporated off
  4. additionTo the obtained fraction was added water (200 mL)
  5. filtrationThe mixture was filtered by suction
  6. customdried

Sources & evidence

ORD record
ord-4eaa18e3dea24460b88bad70eb236bc6
Source dataset
uspto-grants-2014_09
Patent number
US08822465B2

Reaction notes

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