反应详情

温度

120 °C

Intermediate j (9.2 g, 0.035 mol) was added to a mixed solvent of glacial acetic acid (100 mL) and HCl (72 mL, 0.86 mol). The mixture was warmed up to 120° C. and reacted under reflux for 4 h. The solvent was evaporated off. To the obtained fraction was added water (200 mL). The mixture was filtered by suction and dried to produce Intermediate g (6.5 g) in a yield of 55%.

1. customreacted
2. temperatureunder reflux for 4 h
3. customThe solvent was evaporated off
4. additionTo the obtained fraction was added water (200 mL)
5. filtrationThe mixture was filtered by suction
6. customdried