Toluene → 4-(1-Methyl-1-methylcarbamoyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 685472Notes

Reaction equation

HRID 685472 reaction equation
[Ag:29]=[O:30].[Br:1][C:2]([C:3](=[O:4])[NH:5][CH3:6])([CH3:7])[CH3:8].[C:9](=[O:10])([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[N:16]1[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1.[CH3:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1>>[C:2]([C:3](=[O:4])[NH:5][CH3:6])([CH3:7])([CH3:8])[N:19]1[CH2:18][CH2:17][N:16]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:21][CH2:20]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 92152Silver(II) oxideHCID 143452tert-Butyl piperazine-1-carboxylateHCID 2875602-Bromo-N,2-dimethylpropanamide

Product 1

HCID 574939964-(1-Methyl-1-methylcarbamoyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-7ef05ede83084002a353c92fdd810e9d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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