Hydrochloric Acid → 4-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride

HRID 68551Notes

Reaction equation

HRID 68551 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:21][O:20][C:18]1[CH:19]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=[CH:16][N:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66569709Tert-butyl 4-(6-methoxypyrimidin-4-yl)piperazine-1-carboxylate

Product 1

HCID 457890164-Methoxy-6-(piperazin-1-yl)pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

8.61 g 4-(6-Methoxy-pyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester were stirred in 4 mol/L HCl solution in dioxane for 1 h. The precipitates was filtered, washed with dioxane and dried to yield 5.17 g of the desired compound.

Workup

  1. filtrationThe precipitates was filtered
  2. washwashed with dioxane
  3. customdried

Sources & evidence

ORD record
ord-e87ea1655a2c48908d1f21d8f951fece
Source dataset
uspto-grants-2014_09
Patent number
US08822464B2

Reaction notes

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