反应详情

温度

65 °C

2.7 mL Thionylchloride was dropped to 5 g 5-fluor-pyridine-2-carboxylic acid in 50 mL methanol. The reaction was stirred for 2 h at 65° C. in a sealed micro wave vial. The solvents were removed and the residue was desolved in a mixture of DCM and methanol and filtered over silica gel. The filtrate was evaporated to give 5.9 g of the desired product.

1. customThe solvents were removed
2. additionthe residue was desolved in a mixture of DCM and methanol
3. filtrationfiltered over silica gel
4. customThe filtrate was evaporated