Tetrahydrofuran → (2-Amino-5-bromo-pyridin-3-yl)-(2-trifluoromethoxy-phenyl)-methanone

HRID 685668Notes

Reaction equation

HRID 685668 reaction equation
[Br:1][c:2]1[c:3]([O:8][C:9]([F:10])([F:11])[F:12])[cH:4][cH:5][cH:6][cH:7]1.[CH2:13]([Li:14])[CH2:15][CH2:16][CH3:17].[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[NH2:18][c:19]1[c:20]([C:21](=[O:22])[N:23]([O:24][CH3:25])[CH3:26])[cH:27][c:28]([Br:31])[cH:29][n:30]1>>[c:2]1([C:21]([c:20]2[c:19]([NH2:18])[n:30][cH:29][c:28]([Br:31])[cH:27]2)=[O:22])[c:3]([O:8][C:9]([F:10])([F:11])[F:12])[cH:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 27772661-Bromo-2-(trifluoromethoxy)benzeneHCID 596997242-amino-5-bromo-N-methoxy-N-methylnicotinamideHCID 178418339Butyllithium

Product 1

HCID 59700140(2-Amino-5-bromo-pyridin-3-yl)-(2-trifluoromethoxy-phenyl)-methanone

Sources & evidence

ORD record
ord-c368b25d18664edbb5b10c3d190ddc1d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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