Dimethyl Sulfoxide → 2-[3,5-Bis(trifluoromethyl)phenyl]-n{4-(4-fluoro-2-methylphenyl)-6-[8a-(hydroxymethyl)hexahydropyrrolo[1,2-a]pyrazin-2(1h)-yl]-3-pyridinyl}-n,2-dimethylpropanamide
Reaction equation
[C:48](=[O:49])([O-:50])[O-:51].[CH2:1]1[C:2]2([CH2:10][OH:11])[N:3]([CH2:4][CH2:5][NH:6]1)[CH2:7][CH2:8][CH2:9]2.[CH3:54][S:55]([CH3:56])=[O:57].[F:12][C:13]([c:14]1[cH:15][c:16]([C:24]([C:25](=[O:26])[N:27]([CH3:28])[c:29]2[cH:30][n:31][c:32]([Cl:43])[cH:33][c:34]2-[c:35]2[c:36]([CH3:42])[cH:37][c:38]([F:41])[cH:39][cH:40]2)([CH3:44])[CH3:45])[cH:17][c:18]([C:20]([F:21])([F:22])[F:23])[cH:19]1)([F:46])[F:47].[K+:52].[K+:53].[OH2:58]>>[CH2:1]1[C:2]2([CH2:10][OH:11])[N:3]([CH2:4][CH2:5][N:6]1[c:32]1[n:31][cH:30][c:29]([N:27]([C:25]([C:24]([c:16]3[cH:15][c:14]([C:13]([F:12])([F:46])[F:47])[cH:19][c:18]([C:20]([F:21])([F:22])[F:23])[cH:17]3)([CH3:44])[CH3:45])=[O:26])[CH3:28])[c:34](-[c:35]3[c:36]([CH3:42])[cH:37][c:38]([F:41])[cH:39][cH:40]3)[cH:33]1)[CH2:7][CH2:8][CH2:9]2Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-44ad4d6e28d247d38ea356faf520e1f3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…