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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 685918Generated: October 26, 2026

Diethyl Ether → 1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid

https://huagongshe.com/reaction/685918

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl EtherHCID 3283—
ReactantDichloromethaneHCID 6344—
ReactantTrifluoroacetic acidHCID 6422—
Reactant3-(2,4-Difluorophenyl)acrylic AcidHCID 603502—
ReactantN-tert-Butyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)amineHCID 22228418—
Product1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acidHCID 22640765—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (3/10)
ORD IDord-ad9e53f4e8f44c2ab764f73572389829
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (3/10)