Diethyl Ether → 1-tert-Butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylic acid
Reaction equation
[CH3:21][O:22][CH2:23][N:24]([C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:29][Si:30]([CH3:31])([CH3:32])[CH3:33].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Cl:39][CH2:40][Cl:41].[F:1][c:2]1[c:3]([CH:9]=[CH:10][C:11](=[O:12])[OH:13])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[OH:14][C:15]([C:16]([F:17])([F:18])[F:19])=[O:20]>>[F:1][c:2]1[c:3]([CH:9]2[CH:10]([C:11](=[O:12])[OH:13])[CH2:23][N:24]([C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:29]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-ad9e53f4e8f44c2ab764f73572389829
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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