Tetrahydrofuran → 2,5-Difluoro-N-{2-fluoro-3-[5-(2-{[1-(methylsulfonyl)-4-piperidinyl]amino}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide
Reaction equation
[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:38][S:39](=[O:40])(=[O:41])[N:42]1[CH2:43][CH2:44][CH:45]([NH2:48])[CH2:46][CH2:47]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:37])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][c:33]([F:35])[cH:34]4)[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1>>[c:2]1([NH:48][CH:45]2[CH2:44][CH2:43][N:42]([S:39]([CH3:38])(=[O:40])=[O:41])[CH2:47][CH2:46]2)[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:37])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][c:33]([F:35])[cH:34]4)[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-e14fb474a7c24ea3938356f97a510678
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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