反应详情

Into a 50-mL 3-necked round-bottom flask, was placed a solution of tert-butyl 4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazine-1-carboxylate (100 mg, 0.24 mmol, 1.00 equiv) in dichloromethane (20 mL). Hydrogen chloride (g) was then introduced at 0-5° C. The resulting solution was stirred for 1 h at room temperature. The solids were collected by filtration to yield 3-(methylthio)-1-phenyl-6-(piperazin-1-yl)-1H-indazole hydrochloride as a yellow solid.

1. customInto a 50-mL 3-necked round-bottom flask, was placed
2. filtrationThe solids were collected by filtration