反应详情

A 100-mL round-bottom flask was purged, flushed and maintained with a hydrogen atmosphere, then, was added a solution of 3-(methylthio)-6-nitro-1-phenyl-1H-indazole (3.5 g, 12.28 mmol, 1.00 equiv) in ethyl acetate (30 mL), Palladium carbon (2.2 g), bubbled with H2 (gas). The resulting solution was stirred for 48 min at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 3-(methylthio)-1-phenyl-1H-indazol-6-amine as brown oil. MS: 256 (MH+)

1. customA 100-mL round-bottom flask was purged
2. customflushed
3. temperaturemaintained with a hydrogen atmosphere
4. custombubbled with H2 (gas)
5. filtrationThe solids were filtered out
6. concentrationThe resulting mixture was concentrated under vacuum