Hydrochloric Acid → HCID 67449505, compound

HRID 68687Notes

Reaction equation

HRID 68687 reaction equation
[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH:20]4[CH2:25][CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21]4)=[O:19])[CH2:14][CH2:13]3)=[CH:9][CH:10]=2)[N:5]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[N:4]=1.[ClH:39]>ClCCl>[ClH:39].[CH3:1][S:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH:20]4[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]4)=[O:19])[CH2:14][CH2:13]3)=[CH:9][CH:10]=2)[N:5]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67448638tert-butyl 3-(1-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazine-4-carbonyl)piperidine-1-carboxylate

Product 1

HCID 67449505HCID 67449505, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Into a 50-mL 3-necked round-bottom flask, was placed a solution of tert-butyl 3-(1-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazine-4-carbonyl)piperidine-1-carboxylate (80 mg, 0.15 mmol, 1.00 equiv) in dichloromethane (10 mL). To the resulting mixture, HCl (g) was introduced at 0-5° C. The resulting solution was stirred for 1 h at room temperature. The solids were collected by filtration, then washed with diethyl ether (3×10 mL) to yield (4-(3-(methylthio)-1-phenyl-1H-indazol-6-yl)piperazin-1-yl)(piperidin-3-yl)methanone hydrochloride as a yellow solid.

Workup

  1. customInto a 50-mL 3-necked round-bottom flask, was placed
  2. filtrationThe solids were collected by filtration
  3. washwashed with diethyl ether (3×10 mL)

Sources & evidence

ORD record
ord-a36c217104064cb4bf036be3e89a9483
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

Loading…