Tetrahydrofuran → 5-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid ethyl ester

HRID 687060Notes

Reaction equation

HRID 687060 reaction equation
[Br:5][c:6]1[c:7]([CH3:28])[cH:8][c:9]([C:11]2=[N:12][O:13][C:14]([C:16]([F:17])([F:18])[F:19])([c:20]3[cH:21][c:22]([Cl:27])[cH:23][c:24]([Cl:26])[cH:25]3)[CH2:15]2)[s:10]1.[CH2:29]([CH3:30])[O:31][C:32](=[O:33])[C:34]#[N:35].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:1][CH2:2][Mg:3][Cl:4]>>[c:6]1([C:32]([O:31][CH2:29][CH3:30])=[O:33])[c:7]([CH3:28])[cH:8][c:9]([C:11]2=[N:12][O:13][C:14]([C:16]([F:17])([F:18])[F:19])([c:20]3[cH:21][c:22]([Cl:27])[cH:23][c:24]([Cl:26])[cH:25]3)[CH2:15]2)[s:10]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 69336Ethyl cyanoformateHCID 866580393-(5-Bromo-4-methyl-thiophen-2-yl)-5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazoleHCID 178461633HCID 178461633, compound

Product 1

HCID 665872885-[5-(3,5-Dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-2928a208746844fab5021e27d82019f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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