Hydrochloric Acid → 1-(3-Methoxy-1-phenyl-1H-indazol-6-yl)-3-(piperidin-4-yl)imidazolidin-2-one hydrochloride

HRID 68716Notes

Reaction equation

HRID 68716 reaction equation
Br[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([O:17][CH3:18])=[N:7][N:8]2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.C(OC([N:26]1[CH2:31][CH2:30][CH:29]([N:32]2[CH2:36][CH2:35][NH:34][C:33]2=[O:37])[CH2:28][CH2:27]1)=O)(C)(C)C.[ClH:38]>>[ClH:38].[CH3:18][O:17][C:6]1[C:5]2[C:9](=[CH:10][C:2]([N:34]3[CH2:35][CH2:36][N:32]([CH:29]4[CH2:28][CH2:27][NH:26][CH2:31][CH2:30]4)[C:33]3=[O:37])=[CH:3][CH:4]=2)[N:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 46344059tert-Butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylateHCID 674471756-Bromo-3-methoxy-1-phenyl-1H-indazole

Product 1

HCID 674459591-(3-Methoxy-1-phenyl-1H-indazol-6-yl)-3-(piperidin-4-yl)imidazolidin-2-one hydrochloride

Procedure

The title compound was prepared according to the procedure as described in Example 57 reacting 6-bromo-3-methoxy-1-phenyl-1H-indazole and 4-(2-oxo-imidazolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester, followed by de-protection with HCl.

Sources & evidence

ORD record
ord-6cc0216711404497be6dba4ecbc74e1e
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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