Hydrochloric Acid → HCID 178437921, compound

HRID 68732Notes

Reaction equation

HRID 68732 reaction equation
[ClH:1].[CH2:2]([C:4]1[C:12]2[C:7](=[N:8][C:9]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:10][C:11]=2[OH:13])[N:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:5]=1)[CH3:3].C(OC([N:33]1[CH2:38][CH2:37][C:36](=O)[CH2:35][CH2:34]1)=O)(C)(C)C.Cl>>[ClH:1].[N:17]1([CH:36]2[CH2:37][CH2:38][NH:33][CH2:34][CH2:35]2)[CH2:16][CH2:15][CH:14]([C:9]2[N:8]=[C:7]3[N:6]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[N:5]=[C:4]([CH2:2][CH3:3])[C:12]3=[C:11]([OH:13])[N:10]=2)[CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 178437922HCID 178437922, compound

Product 1

HCID 178437921HCID 178437921, compound

Procedure

The title compound was prepared according to the procedure as described in Example 88 reacting via reductive amination 3-ethyl-1-phenyl-6-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ol hydrochloride and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester followed by de-protection of the adduct with HCl.

Sources & evidence

ORD record
ord-685bfb59c30e4b04bb7312e3a2b35bcb
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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