Hydrochloric Acid → HCID 178437923, compound

HRID 68733Notes

Reaction equation

HRID 68733 reaction equation
[ClH:1].[CH2:2]([C:4]1[C:12]2[C:7](=[N:8][C:9]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)=[N:10][C:11]=2[OH:13])[N:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:5]=1)[CH3:3].C(OC([N:33]1[CH2:38][CH2:37][CH:36]([C:39](O)=[O:40])[CH2:35][CH2:34]1)=O)(C)(C)C.Cl>>[ClH:1].[CH2:2]([C:4]1[C:12]2[C:7](=[N:8][C:9]([CH:14]3[CH2:15][CH2:16][N:17]([C:39]([CH:36]4[CH2:37][CH2:38][NH:33][CH2:34][CH2:35]4)=[O:40])[CH2:18][CH2:19]3)=[N:10][C:11]=2[OH:13])[N:6]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:5]=1)[CH3:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acidHCID 178437922HCID 178437922, compound

Product 1

HCID 178437923HCID 178437923, compound

Procedure

The title compound was prepared according to the procedure as described in Example 87 reacting 3-ethyl-1-phenyl-6-piperidin-4-yl-1H-pyrazolo[3,4-d]pyrimidin-4-ol hydrochloride and piperidine-1,4-dicarboxylic acid mono-tert-butyl ester followed by de-protection of the adduct with HCl.

Sources & evidence

ORD record
ord-36048ad9679f481fa856267a758f62b9
Source dataset
uspto-grants-2014_09
Patent number
US08822447B2

Reaction notes

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