反应详情

A mixture of 8-(3-phenyl-[1,2,4]oxadiazol-5-yl)-1,4-dioxa-8-aza-spiro[4.5]decane (660 mg), conc. aqueous HCl (5 mL) and water (5 mL) is kept at room temperature over night. The mixture is basified with conc. aqueous ammonia and the precipitate is filtered off and dissolved in dichloromethane. The resulting solution is dried over Na2SO4 and concentrated in vacuo to give the title compound. TLC: rf=0.33 (silica gel, hexane/ethyl acetate 2:1); Mass spectrum (ESI+): m/z=244 [M+H]+.

1. waitis kept at room temperature over night
2. filtrationthe precipitate is filtered off
3. dissolutiondissolved in dichloromethane
4. dry with materialThe resulting solution is dried over Na2SO4
5. concentrationconcentrated in vacuo