Thionyl Chloride → 4-(4-Methyl-oxazol-5-yl)-benzoyl chloride

HRID 68762Notes

Reaction equation

HRID 68762 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:19]=[CH:18][C:14]([C:15](O)=[O:16])=[CH:13][CH:12]=1>ClCCl>[CH3:5][C:6]1[N:7]=[CH:8][O:9][C:10]=1[C:11]1[CH:19]=[CH:18][C:14]([C:15]([Cl:3])=[O:16])=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 682900554-(4-Methyloxazol-5-yl)benzoic acid

Product 1

HCID 866782114-(4-Methyl-oxazol-5-yl)-benzoyl chloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Thionyl chloride (2.00 mL) is added to 4-(4-methyl-oxazol-5-yl)-benzoic acid (400 mg) in dichloromethane (5 mL) and the mixture is stirred for two days at room temperature. The solvent is evaporated to give the title compound, which is used without further purification for the next reaction step.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-00937668ffff45a6bfe0b720f329e30d
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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