Cyclopropylamine → 4-Cyclopropylamino-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

HRID 68768Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10]([CH3:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:16]1([NH2:19])[CH2:18][CH2:17]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][CH:16]2[CH2:18][CH2:17]2)[CH:10]([CH3:15])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 22644642tert-Butyl 3-methyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 682899444-Cyclopropylamino-3-methyl-piperidine-1-carboxylic acid tert-butyl ester

Procedure

The title compound is prepared from 3-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester and cyclopropylamine following a procedure analogous to that described in Intermediate 7. LC (method 3): tR=1.30 min; Mass spectrum (ESI+): m/z=255 [M+H]+.

Sources & evidence

ORD record: ord-301deab23fa241cbba0c9445cfdc57a8
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822471B2

Reaction notes

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