1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile → 8-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-1,4-dioxa-8-aza-spiro[4.5]decane

HRID 68777Notes

Reaction equation

HRID 68777 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:11]#[N:12])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[OH:13][NH:14][C:15](=N)[C:16]([CH3:19])([CH3:18])[CH3:17]>>[C:16]([C:15]1[N:12]=[C:11]([N:8]2[CH2:7][CH2:6][C:5]3([O:4][CH2:3][CH2:2][O:1]3)[CH2:10][CH2:9]2)[O:13][N:14]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 866782101,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrileHCID 178446865HCID 178446865, compound

Product 1

HCID 682895678-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-1,4-dioxa-8-aza-spiro[4.5]decane

Procedure

The title compound is prepared from 1,4-dioxa-8-aza-spiro[4.5]decane-8-carbonitrile and N-Hydroxy-2,2-dimethyl-propionamidine following a procedure analogous to that described in Intermediate 5. LC (method 14): tR=1.53 min; Mass spectrum (ESI+): m/z=268 [M+H]+.

Sources & evidence

ORD record
ord-1114c98c459c4f22866f7fbd9a7c754d
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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