HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile → 8-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-1,4-dioxa-8-aza-spiro[4.5]decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxa-8-aza-spiro[4.5]decane-8-carbonitrile | HCID 86678210 | — |
| Reactant | HCID 178446865 | HCID 178446865 | — |
| Product | 8-(3-tert-Butyl-[1,2,4]oxadiazol-5-yl)-1,4-dioxa-8-aza-spiro[4.5]decane | HCID 68289567 | — |
Reaction Steps
The title compound is prepared from 1,4-dioxa-8-aza-spiro[4.5]decane-8-carbonitrile and N-Hydroxy-2,2-dimethyl-propionamidine following a procedure analogous to that described in Intermediate 5. LC (method 14): tR=1.53 min; Mass spectrum (ESI+): m/z=268 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822471B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1114c98c459c4f22866f7fbd9a7c754d |
| Source note | uspto-grants-2014_09 |