HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 68783Generated: October 29, 2026
Hydrochloric Acid → 4-(1H-1,2,4-Triazol-1-yl)benzoic acid
https://huagongshe.com/reaction/68783
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Benzoic acid, 4-fluoro-, ethyl ester | HCID 67976 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(1H-1,2,4-Triazol-1-yl)benzoic acid | HCID 736531 | — |
Reaction Steps
To a solution of ethyl 4-fluoro-benzoate (1.68 g) in N-methyl-pyrrolidinone (10 mL) is added 1,2,4-triazole (2.5 g) and K2CO3 (1.5 g) and the mixture is heated at 190° C. in a microwave oven for 30 min. After cooling to room temperature, the mixture is acidified with 2 M aqueous HCl and the precipitate is filtered off, washed with a small amount of water and methanol/dichloromethane and dried by suction to give the acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822471B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-8f9dd6f9592945aebed360fa170cda28 |
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| Source note | uspto-grants-2014_09 |
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