反应详情

温度

190 °C

To a solution of ethyl 4-fluoro-benzoate (1.68 g) in N-methyl-pyrrolidinone (10 mL) is added 1,2,4-triazole (2.5 g) and K2CO3 (1.5 g) and the mixture is heated at 190° C. in a microwave oven for 30 min. After cooling to room temperature, the mixture is acidified with 2 M aqueous HCl and the precipitate is filtered off, washed with a small amount of water and methanol/dichloromethane and dried by suction to give the acid.

1. temperatureAfter cooling to room temperature
2. filtrationthe precipitate is filtered off
3. washwashed with a small amount of water and methanol/dichloromethane
4. customdried by suction
5. customto give the acid