反应详情

A solution of 8-(5-chloropyrimidin-2-yl)-1,4-dioxa-8-azaspiro[4.5]decane (4.2 g) in 6 M aqueous HCl (50 mL) is stirred at room temperature for 60 h. The solution is cooled in ice bath and 4 M aqueous NaOH solution (90 mL) is added in portions to make the solution strongly basic (pH˜14). The mixture is extracted with dichloromethane (2×200 mL) and the combined organic layers are dried over Na2SO4, filtered and concentrated to yield the title compound.

1. temperatureThe solution is cooled in ice bath
2. extractionThe mixture is extracted with dichloromethane (2×200 mL)
3. dry with materialthe combined organic layers are dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated