Dichloromethane → tert-butyl 3-{[(4-{[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]carbamoyl}-3-[tetrahydro-2H-pyran-4-yl(trifluoroacetyl)amino]phenyl)amino]methyl}azetidine-1-carboxylate
Reaction equation
[C:62]([O:63][BH-:64]([O:65][C:66](=[O:67])[CH3:68])[O:69][C:70](=[O:71])[CH3:72])(=[O:73])[CH3:74].[CH3:75][N+:76]([CH3:77])([CH3:78])[CH3:79].[CH:42](=[O:43])[CH:44]1[CH2:45][N:46]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:47]1.[Cl:80][CH2:81][Cl:82].[F:1][c:2]1[cH:3][c:4]([CH2:5][c:6]2[cH:7][c:8]3[c:9]([NH:15][C:16]([c:17]4[c:18]([N:24]([C:25]([C:26]([F:27])([F:28])[F:29])=[O:30])[CH:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[cH:19][c:20]([NH2:23])[cH:21][cH:22]4)=[O:37])[n:10][nH:11][c:12]3[cH:13][cH:14]2)[cH:38][c:39]([F:41])[cH:40]1.[OH:55][C:56]([C:57]([F:58])([F:59])[F:60])=[O:61]>>[F:1][c:2]1[cH:3][c:4]([CH2:5][c:6]2[cH:7][c:8]3[c:9]([NH:15][C:16]([c:17]4[c:18]([N:24]([C:25]([C:26]([F:27])([F:28])[F:29])=[O:30])[CH:31]5[CH2:32][CH2:33][O:34][CH2:35][CH2:36]5)[cH:19][c:20]([NH:23][CH2:42][CH:44]5[CH2:45][N:46]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:47]5)[cH:21][cH:22]4)=[O:37])[n:10][nH:11][c:12]3[cH:13][cH:14]2)[cH:38][c:39]([F:41])[cH:40]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-de34a42f3288411197da67071ea6497d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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