Ammonia → tert-Butyl [(3-aminooxetan-3-yl)methyl]carbamate

HRID 688020Notes

Reaction equation

[CH2:1]([N:8]([CH2:2][c:3]1[cH:4][cH:5][cH:6][cH:7][cH:22]1)[C:9]1([CH2:13][NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:10][O:11][CH2:12]1)[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[CH3:37][OH:38].[NH3:36].[OH-:39].[OH-:41].[OH:29][C:30]([C:31]([F:32])([F:33])[F:34])=[O:35].[Pd+2:40]>>[NH2:8][C:9]1([CH2:13][NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:10][O:11][CH2:12]1

Participants

Reactant 6

HCID 222Ammonia

HCID 887Methanol

HCID 961Hydroxide2×

HCID 6422Trifluoroacetic acid

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 71262160HCID 71262160, compound

Product 1

HCID 71254478tert-Butyl [(3-aminooxetan-3-yl)methyl]carbamate

Sources & evidence

ORD record: ord-2b4fe950f211401fb51d7d496553d3ec
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (3/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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