6-Chloro-3-pyridinecarbonitrile → N-[1-(5-Cyano-pyridin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68821Notes

Reaction equation

HRID 68821 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Cl[C:25]1[CH:32]=[CH:31][C:28]([C:29]#[N:30])=[CH:27][N:26]=1>>[C:29]([C:28]1[CH:31]=[CH:32][C:25]([N:21]2[CH2:22][CH2:23][CH:18]([N:4]([CH:1]3[CH2:3][CH2:2]3)[C:5](=[O:17])[C:6]3[CH:7]=[CH:8][C:9]([C:12]4[O:16][CH:15]=[N:14][CH:13]=4)=[CH:10][CH:11]=3)[CH2:19][CH2:20]2)=[N:26][CH:27]=1)#[N:30]

Participants

3

Reactant 2

HCID 51520946-Chloro-3-pyridinecarbonitrileHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68351870N-[1-(5-Cyano-pyridin-2-yl)-piperidin-4-yl]-N-cyclopropyl-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 6-chloro-nicotinonitrile following a procedure analogous to that described in Example 19. LC (method 9): tR=2.02 min; Mass spectrum (ESI+): m/z=414 [M+H]+.

Sources & evidence

ORD record
ord-5ab9f93d2fa54335a4e0c08edcececb7
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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