2-Chloro-5-(4-chlorophenyl)pyrimidine → N-{1-[5-(4-Chloro-phenyl)-pyrimidin-2-yl]-piperidin-4-yl}-N-cyclopropyl-4-oxazol-5-yl-benzamide

HRID 68824Notes

Reaction equation

HRID 68824 reaction equation
[CH:1]1([N:4]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[C:5](=[O:17])[C:6]2[CH:11]=[CH:10][C:9]([C:12]3[O:16][CH:15]=[N:14][CH:13]=3)=[CH:8][CH:7]=2)[CH2:3][CH2:2]1.Cl[C:25]1[N:30]=[CH:29][C:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)=[CH:27][N:26]=1>>[Cl:37][C:34]1[CH:33]=[CH:32][C:31]([C:28]2[CH:29]=[N:30][C:25]([N:21]3[CH2:22][CH2:23][CH:18]([N:4]([CH:1]4[CH2:3][CH2:2]4)[C:5](=[O:17])[C:6]4[CH:7]=[CH:8][C:9]([C:12]5[O:16][CH:15]=[N:14][CH:13]=5)=[CH:10][CH:11]=4)[CH2:19][CH2:20]3)=[N:26][CH:27]=2)=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 27610252-Chloro-5-(4-chlorophenyl)pyrimidineHCID 68289931N-Cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide

Product 1

HCID 68351869N-{1-[5-(4-Chloro-phenyl)-pyrimidin-2-yl]-piperidin-4-yl}-N-cyclopropyl-4-oxazol-5-yl-benzamide

Procedure

The title compound is prepared from N-cyclopropyl-4-oxazol-5-yl-N-piperidin-4-yl-benzamide and 2-chloro-5-(4-chloro-phenyl)-pyrimidine following a procedure analogous to that described in Example 19. LC (method 9): tR=2.42 min; Mass spectrum (ESI+): m/z=500/502 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-2b95c79a432c48149477287174ed0cd2
Source dataset
uspto-grants-2014_09
Patent number
US08822471B2

Reaction notes

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